Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A
نویسندگان
چکیده
منابع مشابه
Env-less endogenous retroviruses are genomic superspreaders.
Endogenous retroviruses (ERVs) differ from typical retroviruses in being inherited through the host germline and therefore are a unique combination of pathogen and selfish genetic element. Some ERV lineages proliferate by infecting germline cells, as do typical retroviruses, whereas others lack the env gene required for virions to enter cells and thus behave like retrotransposons. We wished to ...
متن کاملHow Active Are Porcine Endogenous Retroviruses (PERVs)?
Porcine endogenous retroviruses (PERVs) represent a risk factor if porcine cells, tissues, or organs were to be transplanted into human recipients to alleviate the shortage of human transplants; a procedure called xenotransplantation. In contrast to human endogenous retroviruses (HERVs), which are mostly defective and not replication-competent, PERVs are released from normal pig cells and are i...
متن کاملEndogenous retroviruses
Endogenous retroviruses are integral features of vertebrate genomes. Here, Hayward and Katzourakis offer a glimpse into the fascinating world of these mysterious partners in our evolution.
متن کاملFoamy-like endogenous retroviruses are extensive and abundant in teleosts
Recent discoveries indicate that the foamy virus (FV) (Spumavirus) ancestor may have been among the first retroviruses to appear during the evolution of vertebrates, demonstrated by foamy endogenous retroviruses present within deeply divergent hosts including mammals, coelacanth, and ray-finned fish. If they indeed existed in ancient marine environments hundreds of millions of years ago, signif...
متن کاملEndogenous retroviruses and multiple sclerosis.
Endogenous retroviruses are normal constituents in vertebrate genomes. They have been associated with various diseases of presumed autoimmune etiology. However, conclusive evidence of their significance as susceptibility factors in these diseases is still lacking. In our laboratory we have focused attention upon endogenous retroviruses as candidate genes in multiple sclerosis. In this communica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2011
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.2008511